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Science of fasting |
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Periodic fasting and CR prevent aging and rejuvenate the body |
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High-protein diet in middle age poses serious health risk |
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Treatment of Obesity through fasting |
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Management of Diabetes Through Intermittent Fasting |
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Longevity Gene: Another scientific step towards longer lives |
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Cholesterol Lowering Drug Statin Can Extend Lives of Cancer Patients |
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Fasting cycles retard growth of tumors |
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Intermittent Fasting for Prevention Obesity and Diabetes by |
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New compound in red wine (piceatannol) staves off obesity |
| Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention. Aging Male. 2013 Sep 17. Teng NI, Shahar S, Rajab NF, Manaf ZA, Johari MH, Ngah WZ. Objective: Calorie restriction and intermittent fasting are two dietary interventions that can improve aging. Religious fasting also suggested having similar benefit; however, such studies are still scarce. Thus, this study aimed to determine the effect of fasting calorie restriction (FCR) on metabolic parameters and DNA damage among healthy older adult men. Methods: A randomized controlled study was done on men, aged 50-70 years in Klang Valley, Malaysia. Subjects were divided into two groups; FCR (reduction of 300-500 kcal/d combined with 2 days/week of Muslim Sunnah Fasting) and control. Assessment was ascertained at three time point; baseline, weeks 6 and 12. Blood samples were analyzed for lipid profile, DNA damage and malondialdehyde (MDA). Results: The FCR group reduced their energy intake for approximately 18% upon completion of the study. A significant interaction effect was found in body weight, body mass index, fat percentage, fat mass, blood pressure, total cholesterol, low-density lipoprotein cholesterol and the ratio of total cholesterol/high-density lipoprotein cholesterol (p < 0.05). A significant improvement (p < 0.001) in total DNA rejoining cells and MDA (p < 0.05) was also observed in the FCR group. Conclusion: FCR improved metabolic parameters and DNA damage in healthy older adult men. Therefore, there is a need to further examine the mechanism of FCR. |
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