asthma >> Anti-Aging Plan

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Asthma can be prevented or cured by means of therapeutic fasting and caloric restriction. Clinical evidence:

Diet-induced weight loss in obese children with asthma: a randomized controlled trial.

Clin Exp Allergy. 2013 Jul;43(7):775-84. doi: 10.1111/cea.12115.

Jensen ME1, Gibson PG, Collins CE, Hilton JM, Wood LG.

BACKGROUND:

Obesity is highly prevalent in asthmatic children and associated with worse clinical outcomes. Energy restriction to induce weight loss in asthmatic children has not been investigated in a randomized controlled trial (RCT).

OBJECTIVE:

To assess if (1) weight loss can be achieved in obese asthmatic children using a dietary intervention; and (2) changes in asthma outcomes occur following diet-induced weight loss.

METHODS:

In a 10-week pilot RCT, obese asthmatic children, aged 8-17 years, were randomized to a wait-list control (WLC) (n = 15) or dietary-intervention group (DIG) (n = 13). Lung function, Asthma Control Questionnaire (ACQ) score, and sputum and systemic inflammation were assessed at baseline and post-intervention. (Australian New Zealand Clinical Trials Registry: ACTRN12610000955011).

RESULTS:

Body mass index (BMI) z-score reduced significantly in the DIG vs. the WLC (-0.2 [-0.4, -0.1] vs. 0.0 [-0.1, 0.0], P = 0.014). Expiratory reserve volume (ERV) increased significantly within the DIG, but not compared to the WLC (0.7 [0.0, 1.0] L vs. 0.3 [0.0, 0.8] L, P = 0.355). ACQ improved significantly in the DIG, compared to the WLC (-0.4 [-0.7, 0.0] vs. 0.1 [0.0, 0.6], P = 0.004). Airway and systemic inflammation did not change within the DIG. In comparison, C-Reactive Protein (CRP) increased significantly in the WLC (-0.4 [-0.5, 0.4] vs. 0.7 [-0.1, 1.9], P = 0.037). Change (∆) in BMI z-score correlated with ∆CRP (r = 0.47, P = 0.012) and ∆exhaled nitric oxide (eNO) (r = 0.46, P = 0.034), and ∆ACQ was associated with ∆CRP (r = 0.43, P = 0.029).

CONCLUSION AND CLINICAL RELEVANCE:

Dietary intervention can induce acute weight loss in obese asthmatic children with subsequent improvements in static lung function and asthma control. Systemic and airway inflammation did not change following weight loss. However, changes in BMI z-score were associated with changes in airway and systemic inflammation and this requires further investigation in a larger RCT. This is the first weight loss RCT conducted in obese asthmatic children. Diet-induced weight loss can achieve significant improvements in clinical outcomes for obese children with asthma.

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.
Free Radic Biol Med. 2007 Mar 1;42(5):665-74. Epub 2006 Dec 14.
Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, Pearson M, Nassar M, Telljohann R, Maudsley S, Carlson O, John S, Laub DR, Mattson MP.
Department of Surgery, Louisiana State University Medical Center, New Orleans, LA 70006, Erratum in: Free Radic Biol Med. 2007 Nov 1;43(9):1348. Tellejohan, Richard [corrected to Telljohann, Richard].
Asthma is an increasingly common disorder responsible for considerable morbidity and mortality. Although obesity is a risk factor for asthma and weight loss can improve symptoms, many patients do not adhere to low calorie diets and the impact of dietary restriction on the disease process is unknown. A study was designed to determine if overweight asthma patients would adhere to an alternate day calorie restriction (ADCR) dietary regimen, and to establish the effects of the diet on their symptoms, pulmonary function and markers of oxidative stress, and inflammation. Ten subjects with BMI>30 were maintained for 8 weeks on a dietary regimen in which they ate ad libitum every other day, while consuming less than 20% of their normal calorie intake on the intervening days. At baseline, and at designated time points during the 8-week study, asthma control, symptoms, and Quality of Life questionnaires (ACQ, ASUI, mini-AQLQ) were assessed and blood was collected for analyses of markers of general health, oxidative stress, and inflammation. Peak expiratory flow (PEF) was measured daily on awakening. Pre- and postbronchodilator spirometry was obtained at baseline and 8 weeks. Nine of the subjects adhered to the diet and lost an average of 8% of their initial weight during the study. Their asthma-related symptoms, control, and QOL improved significantly, and PEF increased significantly, within 2 weeks of diet initiation; these changes persisted for the duration of the study. Spirometry was unaffected by ADCR. Levels of serum beta-hydroxybutyrate were increased and levels of leptin were decreased on CR days, indicating a shift in energy metabolism toward utilization of fatty acids and confirming compliance with the diet. The improved clinical findings were associated with decreased levels of serum cholesterol and triglycerides, striking reductions in markers of oxidative stress (8-isoprostane, nitrotyrosine, protein carbonyls, and 4-hydroxynonenal adducts), and increased levels of the antioxidant uric acid. Indicators of inflammation, including serum tumor necrosis factor-alpha and brain-derived neurotrophic factor, were also significantly decreased by ADCR. Compliance with the ADCR diet was high, symptoms and pulmonary function improved, and oxidative stress and inflammation declined in response to the dietary intervention. These findings demonstrate rapid and sustained beneficial effects of ADCR on the underlying disease process in subjects with asthma, suggesting a novel approach for therapeutic intervention in this disorder.ie restriction, weight normal, aging plan, anti aging plan, opatija riviera.

Fasting: an important issue in asthma management compliance.
Ann Allergy Asthma Immunol. 2006 Sep;97(3):370-4.
Erkekol FO, Celik GE, Keskin O, Güllü E, Mungan D, Misirligil Z.
Division of Allergic Diseases, School of Medicine, Ankara University, Turkey.
BACKGROUND: Fasting, neither eating nor drinking anything between dawn (sahur time) and sundown (iftar time), may have an important role in the treatment and follow-up of asthmatic patients in countrie where most of the population is Muslim.
OBJECTIVE: To analyze the effects of fasting on outpatient asthmatic patients.
METHODS: One hundred twenty-one fasting patients were evaluated for attendance at follow-up visits, attitudes about undergoing diagnostic investigations, and opinions and practices regarding medication use during fasting. Their sources of knowledge about asthma, fasting, and medication consumption were also evaluated.
RESULTS: Ninety percent of fasting patients reported no harm with respect to religion of visiting physicians while fasting. Although 96% of the patients stated that inhaled medication could be used, only 13% continued to use medication in the same manner as when they were not fasting. Most patients rearranged their medication-consumption hours. Although 96% of the patients received general information about asthma from their physicians, rates of receiving information about the fasting-medication use relationship from physicians and religious sources were similar (37% and 32%, respectively).
CONCLUSION: Most Muslim asthmatic patients do not consider asthma to be a drawback to
fasting, and they continue fasting by rearranging their medication consumption times. During Ramadan, patients should be questioned about this subject and should be followed up carefully for asthma control at regular visits.

Effectiveness of short courses of fasting in pre-asthma and asthma patients
[Article in Ukrainian]
Lik Sprava 2002 Apr-Jun;(3-4):79-81.
Tovt-Korshyns'ka MI, Spivak MIa, Chopei IV.
In patients with preasthma and bronchial asthma, short-term courses of fasting dietotherapy (FDT) with a 7-day fasting period proved to be effective, as evidenced by clinical-and-functional and laboratory investigations. The incidence rate of viral infections was much lower with short-term courses compared to long-term courses. Too low an effect, if any, with
FDT short-term courses can be explained by excess of the patient's body weight. Short-term FDT courses with a 3-day fasting period have been found out to result in a significant decrease in the level of anxiety, as measured by Spilberger Anxiety Inventory.

Enterosorption and therapeutic fasting in the treatment of patients with bronchial asthma. (Enterosorbtsiia i lechebnoe golodanie v terapii bol'nykh bronkhial'noi astmoi).
Asthma Klin Med (Mosk) 1991 Apr;69(4):54-6.
Dzhugostran VIa; Niamtsu ET; Zlepka VD; Marchenko IuG.
To rise the effectiveness of the treatment and reduce its duration as well as to out acidosis, 18 patients with bronchial asthma and chronic obstructive bronchitis were treated by fasting diet and enterosorption. The scheme of the diet was conventional, with intake of SKNP-2 enterosorbent.

Fasting-dietetic therapy as a non-medicinal method of choice in complicated cases of asthmatic bronchitis and bronchial asthma: pathophysiologic shifts, indications for treatment, results (review with presentation of author's observations)
Ter Arkh. 1991;63(3):100-3. [Article in Russian]. Kokosov AN, Osinin SG, Faustova ME. Use of controlled therapeutic fasting in bronchial asthma. Adravookhr Belorus 1979; 0 (9): 55-58. Gorbachev VV, Sytyi VP, Sizova EP, Vasnev VI, Boyarintseva AV.

According to Dr. Fuhrman’s observations ( Dr. Joel Fuhrman M.D."Fasting and Eating for Health", St. Martin’s Griffin, New York, 1995) the more severe the asthma and the greater the dependency on medication, the longer it takes to archive a recovery when we apply natural methods. He have found that a long fast, or sometimes two fasts with impeccable dietary habits in between, is usually essential for the resolution when the patient has been dependent on multiple medications for many years. The beneficial effects of fasting in asthmatics have been well documented in the Russian medical literature. Their clinical trials illustrated that more than 75 percent of patients had greatly improved conditions or never had symptoms of asthma again after fasting.

Exception from Dr. Fuhrman book (for asthmatic patients)
“… Beth was a severe asthmatic and had history of recurrent hospitalizations before she came under my care. At first we avoided further hospitalization only by keeping her on high doses of inhalted steroids, as well as other medication. Frequently, we had to add oral steroids in addition to the inhaled steroids when her condition took a turn for the worse. She was never in good control of her asthma even with high doses of medication and always endured wheezing and poor air flow. She awoke nightly to uses her breathing machines. Although she followed a careful diet, we saw no improvement. We talked about fasting, but she was not able to set a definite date to begin a fast because of her work responsibilities and her fear of undertaking a prolonged fast. Slowly, through the fiest week of the fast, as Beth’s breathing improved, we tapered her medication. Within four days of beginning the fast she developed a red, itchy rash all over her arms and legs. This represented the elimination of retained toxins that her body had never effectively been able to remove while she was eating and taking medication, especially because she was habitually on steroids. I assume her that this type of rash is extremely common in patients who have been on steroids in the past, because these medications suppress the body’s self-cleansing and detoxification mechanisms, permitting the retention of tissue wate products.Taking an oatmeal bath a few times daily helped relieve her itching. The rash began to clear, her breathing improved. And by the eighth day of the fast we were able to safely stop all medications. Beth continued her fast for 21 days, and for the first time in years was on no medication or inhalers. I was unsure where or not she still had a touch of asthma left; her peak flow measurements on spirometer were still slightly below normal, and I suspected that, in such a severe case, she should undertake another fast six months after the first one to make sure her body had adequately normalized and healed.

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Life extension and disease treatment through periodic fasting and caloric restriction - the most powerful scientifically proven natural anti-aging method

More information about Fasting&Cleansing program read here

Life extension and
disease treatment through
periodic fasting and
caloric restriction -
the most powerful
scientifically proven
natural anti-aging method